Overview of Goldenseal
Botanical Name: Hydrastis canadensis
Goldenseal is a rare medicinal plant often used in combination with Echinacea for immune health. According to the State of California, goldenseal root powder causes cancer [Proposition 65 Warning].
Conflicting (Unclear):insufficient information
Limited Evidence:insufficient information
No Evidence:insufficient information
No Clinical Research:All other conditions.
- Mouth Sores
- Numbness, Prickling, or Tingling in the Arms and Legs
- Skin Inflammation
- Stomach Cramping and Pain
- Avoid or contact a licensed healthcare practitioner, if you have a glucose-6-phosphate dehydrogenase (G6PD) deficiency, and heart or blood vessel disease especially hypertension, heart failure, or irregular heartbeats.
- Adverse events relating to goldenseal may include: dangerous heart rhythms, decrease white blood cell counts, paralysis, respiratory depression, seizures, and slow pulse.
- Goldenseal taken over extended periods may cause digestive disorders, mucous membrane irritation, constipation, excitatory states, hallucinations, and occasional deliria.
- Goldenseal can cause jaundice and hemolytic anemia in people with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
- A case of severe hypernatremia and hyperosmolality in a patient with diabetic ketoacidosis.
- There was a case of photosensitivity of a goldenseal / ginseng / bee pollen combination.
There is not enough research on the use of supplements containing goldenseal during pregnancy and breast-feeding, so consult a licensed healthcare practitioner before use or avoid use. However, women with a history of miscarriages should NOT take goldenseal. [1-5]
Goldenseal is not a "drug", the best doses have not been thoroughly established. Make sure to follow the specific product instructions and take as directed on the label, or consult a licensed healthcare practitioner before use. Large doses of goldenseal may cause nervousness, depression, exaggerated reflexes, irritation of the mouth, stomach and mucous membranes, and even respiratory paralysis, seizures, heart and blood vessel collapse, or death. 
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