Pygeum Supplement

Scientific Name: Prunus africana

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Order: Rosales

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Family: Rosaceae

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Pygeum is sometimes combined with saw palmetto to treat benign prostate hyperplasia (BPH) and lower urinary tract symptoms (LUTS).

Strong:

insufficient information

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Good:

• Benign Prostate Hyperplasia (BPH)/Lower Urinary Tract Symptoms (LUTS), pygeum alone and a combination of pygeum / lycopene / Cucurbita pepo / Epilobium parviflorum and pygeum / stinging nettle were effective [1-6]

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Promising:

insufficient information

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Conflicting (Unclear):

insufficient information

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Limited Evidence:

insufficient information

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No Evidence:

insufficient information

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No Clinical Research:

All other conditions.

Side effects may include:

• Side effects have not been studied.

Precautions and Adverse Events:

• Use caution or contact a licensed healthcare practitioner, since there is not enough research on the use of supplements containing pygeum.

[7]

There is not enough research on the use of supplements containing pygeum during pregnancy and breast-feeding, so consult a licensed healthcare practitioner before use or avoid use.

Major:

insufficient information

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Moderate:

insufficient information

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Potential:

• 5-Alpha Reductase Inhibitors

[8]

Pygeum is not a "drug", the best doses have not been thoroughly established. Make sure to follow the specific product instructions and take as directed on the label, or consult a licensed healthcare practitioner before use.

[Afendi et al. 2012]

1. Breza J, Dzurny O, Borowka A, Hanus T, Petrik R, Blane G, Chadha-Boreham H. Efficacy and acceptability of tadenan (Pygeum africanum extract) in the treatment of benign prostatic hyperplasia (BPH): a multicentre trial in central Europe. Curr Med Res Opin. 1998;14(3):127-39. 2. Chatelain C, Autet W, Brackman F. Comparison of once and twice daily dosage forms of Pygeum africanum extract in patients with benign prostatic hyperplasia: a randomized, double-blind study, with long-term open label extension. Urology. 1999 Sep;54(3):473-8. 3. Coulson S, Rao A, Beck SL, Steels E, Gramotnev H, Vitetta L. A phase II randomised double-blind placebo-controlled clinical trial investigating the efficacy and safety of ProstateEZE Max: a herbal medicine preparation for the management of symptoms of benign prostatic hypertrophy. Complement Ther Med. 2013 Jun;21(3):172-9. 4. Hutchison A, Farmer R, Verhamme K, Berges R, Navarrete RV. The efficacy of drugs for the treatment of LUTS/BPH, a study in 6 European countries. Eur Urol. 2007 Jan;51(1):207-15; discussion 215-6. 5. Krzeski T, Kazón M, Borkowski A, Witeska A, Kuczera J. Combined extracts of Urtica dioica and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses. Clin Ther. 1993 Nov-Dec;15(6):1011-20. 6. Mantovani F. Serenoa repens in benign prostatic hypertrophy: analysis of 2 Italian studies. Minerva Urol Nefrol. 2010 Dec;62(4):335-40. 7. Gruenwald J, Brendler T, Jaenicke C, editors. PDR for herbal medicines. 4th ed. Montvale, NJ, USA: Thomson Healthcare; 2007. 8. Gruenwald J, Brendler T, Jaenicke C, editors. PDR for herbal medicines. 4th ed. Montvale, NJ, USA: Thomson Healthcare; 2007. 9. Afendi FM, Okada T, Yamazaki M, Hirai-Morita A, Nakamura Y, Nakamura K, Ikeda S, Takahashi H, Altaf-Ul-Amin M, Darusman LK, Saito K, Kanaya S. KNApSAcK family databases: integrated metabolite-plant species databases for multifaceted plant research. Plant Cell Physiol. 2012 Feb;53(2):e1.