Overview of Passionflower
Botanical Name: Passiflora incarnata
Passionflower is native to eastern North America. Another species, passion fruit (Passiflora edulis, is cultivated for its edible purple fruit. The green fruits of passionflower are edible and turn yellowish when overripe. Some consider passionflower and Passiflora edulis the same species; however, one study [Dhawan et al. 2001] considers them two separate species because of difference in the composition of their compounds.
Conflicting (Unclear):insufficient information
- Anxiety, like oxazepam, but with fewer side effects; and a combination of passionflower / Crataegus / Ballota / Valeriana / Cola / Paullinia was effective [2-3]
- Anxiety Reducer before Surgery [4-5]
- Calming and Anti-Depressive Properties, passionflower with valerian / St. John’s wort 
- Sleep Disorders/Insomnia, a combination of passionflower / valerian / hops was a short-term alternative to zolpidem 
- Nervous Agitation in Children, passionflower with valerian / St. John’s wort 
- Opiate Withdrawal, passionflower with clonidine was more effective even over clonidine alone 
- Sleep Quality, short-term improvement 
- Somatoform Disorder, a complex mixture with butterbur 
- Asthma in Adults, fruit peel from Passiflora edulis 
- Osteoarthritis/Joint Pain, fruit peel from Passiflora edulis 
- Type 2 Diabetes, fruit peel from Passiflora edulis 
No Evidence:insufficient information
No Clinical Research:All other conditions.
- Side effects have not been studied.
- Use caution or contact a licensed healthcare practitioner, since there is not enough research on the use of supplements containing passionflower.
- Liver failure and death due to a kava kava/passionflower combination; though kava kava was believed to be the main culprit.
- The related species, Passiflora edulis (passion fruit), may contain compounds toxic to the liver and pancreas.
- Severe nausea, vomiting, drowsiness, prolonged irregular heartbeat, and rapid heartbeat in one patient.
- Dizziness, confusion, and loss of full control of bodily movements in some patients.
- Fruits of passionflower can potentially alter consciousness.
There is not enough research on the use of supplements containing passionflower during pregnancy and breast-feeding, so consult a licensed healthcare practitioner before use or avoid use.
Passionflower is not a "drug", the best doses have not been thoroughly established. Make sure to follow the specific product instructions and take as directed on the label, or consult a licensed healthcare practitioner before use.
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